the formula
meet the timewarp protocol
Each capsule engineered to target aging at its root: together they cover all 12 Hallmarks of Aging.
The TimeWarp Protocol
designed for maximum impact
dive deep into each capsule
capsule deep dive
CORE.
rebuild your cellular engine.
feel: steady energy • Improved focus • Foundational vitality
Restore Your biological Foundation.
You start the day depleted. CORE restores your cellular engine. It rebuilds the energy cycle, supports healthy DNA expression, and keeps your cells performing like they did years ago.
Formula (Per Serving)
- Calcium Alpha-Ketoglutarate (1000 mg)
- Pterostilbene (50 mg)
- Cycloastragenol (20 mg)
- Vitamin B6 (as pyridoxal-5-phosphate) (10 mg)
- Magnesium Bisglycinate (200 mg)
- Vegan HPMC capsule with natural coloring
Chelated forms
Magnesium as bisglycinate for superior absorption. B6 as active P-5-P your body can use directly.
Pterostilbene over resveratrol
Selected for greater stability and 4x higher bioavailability than standard resveratrol.
Built to anchor the system
Core establishes the metabolic base that Energize and Protect build on.
Core Ingredients
The metabolic foundation. Restores cellular energy infrastructure, enzymatic function, and telomere-aligned longevity biology.
2 capsules per day
Calcium Alpha-Ketoglutarate (Ca-AKG)
1000 mg
Supports cellular energy metabolism and epigenetic regulation.
Pterostilbene
50 mg
Activates sirtuins for cellular defense and DNA repair.
Cycloastragenol
20 mg
Supports telomere maintenance via telomerase activation.
Magnesium Bisglycinate
200 mg
Essential cofactor for 300+ enzymatic reactions and sleep quality.
Vitamin B6 (as P-5-P)
10 mg
Active coenzyme form supporting methylation and amino acid metabolism.
Calcium Alpha-Ketoglutarate (Ca-AKG)
1000 mg
What it does
Alpha-ketoglutarate is a naturally occurring molecule central to the Krebs cycle, the metabolic process your cells use to produce energy. It also serves as a cofactor for enzymes involved in DNA demethylation, connecting cellular metabolism directly to epigenetic regulation.
As we age, circulating AKG levels decline. Supplementing with calcium alpha-ketoglutarate restores AKG in a stable, longevity-oriented calcium salt form.
Why this form
Ca-AKG delivers alpha-ketoglutarate directly in a calcium salt form, without relying on the arginine blend (AAKG) commonly used in sports nutrition. This is a longevity-oriented delivery, not a performance-oriented one.
AKG is produced naturally by every cell in the human body as part of the citric acid cycle. Supplemental Ca-AKG is produced through chemical synthesis.
Impacted hallmarks
Pterostilbene
50 mg
What it does
Pterostilbene is a polyphenol found naturally in blueberries. It belongs to the same family as resveratrol but has roughly 4x higher oral bioavailability and a significantly longer half-life, meaning more of the compound reaches your cells and stays active longer.
Pterostilbene activates sirtuin proteins (particularly SIRT1), a family of enzymes involved in DNA repair, mitochondrial function, and cellular stress resistance. These are the same pathways that caloric restriction activates.
Why this form
Selected over the more well-known resveratrol specifically for its 4x higher bioavailability and superior metabolic stability. Resveratrol is more famous. Pterostilbene is more effective.
Found naturally in blueberries (Vaccinium spp.), grapes, and the heartwood of the Indian kino tree (Pterocarpus marsupium).
Impacted hallmarks
Cycloastragenol
20 mg
What it does
Cycloastragenol is a triterpenoid saponin derived from Astragalus membranaceus, a plant with a long history in traditional Chinese medicine. It is one of a small number of compounds shown to activate telomerase, the enzyme responsible for maintaining telomere length.
Telomeres are protective caps at the ends of chromosomes that shorten with each cell division. When they become critically short, cells enter senescence or die.
Why this form
A rare and specialized compound that adds a differentiated telomere-biology component uncommon in most daily longevity formulas.
Extracted from the root of Astragalus membranaceus, a perennial plant native to northern China and Mongolia.
Impacted hallmarks
Magnesium Bisglycinate
200 mg
What it does
Magnesium is involved in over 300 enzymatic reactions including energy production, DNA synthesis, protein folding, and nervous system regulation. An estimated 50% of adults do not meet adequate intake levels.
Magnesium also plays a critical role in activating vitamin D3 (in the Energize capsule), creating a functional synergy across the protocol.
Why this form
Bisglycinate (chelated) form selected for superior absorption and tolerability. Magnesium oxide, the most common form, has roughly 4% bioavailability. Bisglycinate absorbs significantly better with fewer GI issues.
Magnesium bonded to two molecules of glycine, an amino acid. The chelation protects the mineral through digestion.
Impacted hallmarks
Vitamin B6 (as P-5-P)
10 mg
What it does
Vitamin B6 is involved in over 100 enzyme reactions related to amino acid metabolism, neurotransmitter synthesis, and methylation pathways. It is essential for nervous and immune system function.
Particularly relevant for individuals with MTHFR gene variations that impair B-vitamin conversion.
Why this form
Found naturally in potatoes, bananas, chickpeas, poultry, and fish. Potatoes are one of the richest whole-food sources of B6. Supplemental P-5-P is the pre-activated coenzyme form, manufactured to provide the active metabolite directly without requiring liver conversion.
P-5-P is the active metabolite of vitamin B6. Supplemental P-5-P is manufactured to provide the coenzyme directly. B6 is one of the most common micronutrient gaps in the modern diet, despite being abundant in everyday foods like potatoes and bananas.
Impacted hallmarks
energize.
Reignite Your Cellular Power.
Feel: All-day energy • Clear mind • Elevated performance
POWER YOUR CELLS.
When your cells slow down, so does your energy, focus, and mood. ENERGIZE reignites your mitochondria, the power plants of your cells, so you feel steady, alert, and alive all day.
Formula (Per Serving)
- Nicotinamide mononucleotide (NMN) (350 mg)
- Urolithin A (500 mg)
- Apigenin (50 mg)
- EGCG (Liposomal) (80 mg)
- Rhodiola Rosea (200 mg)
- Vitamin B9 (0.5 mg)
- Vitamin B12 (0.2 mg)
- Vitamin D3 (as Cholecalciferol from Lichen) (0.05 mg)
- Vegan HPMC capsule with natural coloring
Active methylation pair
5-MTHF and methylcobalamin work together to support one-carbon metabolism, bypassing the MTHFR conversion step entirely.
NMN + Urolithin A synergy
Direct NAD precursor paired with a direct mitophagy trigger. Two sides of mitochondrial health in one capsule.
Delivery-upgraded EGCG
Liposomal format selected to overcome EGCG's known stability and bioavailability limitations.
Energize Ingredients
The cellular engine. Supports NAD metabolism, mitochondrial renewal, methylation, and day-to-day resilience.
2 capsules per day
Beta-NMN
350 mg
Direct NAD+ precursor for cellular energy production.
Urolithin A
500 mg
Triggers mitophagy to clear and renew damaged mitochondria.
Rhodiola Rosea
200 mg
Adaptogenic support for stress resilience, energy, and focus.
Liposomal EGCG
80 mg
Bioavailability-enhanced green tea extract for metabolic and antioxidant support.
B9 Folate (as 5-MTHF)
500 mcg
Active methylfolate that bypasses the MTHFR conversion step.
Vitamin B12 (Methylcobalamin)
200 mcg
Active coenzyme B12 for methylation and neurological function.
Vitamin D3
50 mcg (2000 IU)
Supports immune regulation, bone health, and calcium metabolism.
Beta-NMN
350 mg
What it does
NMN is a nucleotide that serves as a direct precursor to NAD+, one of the most critical molecules in human biology. NAD+ is required for hundreds of metabolic reactions including mitochondrial energy production, DNA repair, and sirtuin activation.
NAD+ levels decline significantly with age. By your 50s, circulating NAD+ may be half of what it was in your 20s.
The NMN-to-NAD+ conversion consumes methyl groups, which is why we paired it with 5-MTHF and methylcobalamin in the same capsule to replenish what gets used.
Why this form
Selected over NR, niacin, and NAD+ itself for its direct conversion pathway (one enzymatic step from NAD+) and growing body of human clinical data. Beta-NMN is the bioactive isomer.
Occurs naturally in small amounts in broccoli, cabbage, avocado, and edamame. Supplemental NMN is produced through enzymatic biosynthesis.
Impacted hallmarks
Urolithin A
500 mg
What it does
Urolithin A triggers mitophagy, the process by which cells identify and recycle damaged mitochondria. Instead of accumulating dysfunctional mitochondria, the cell clears them and generates new ones.
Only about 40% of the population has the right gut microbiome to produce urolithin A naturally from pomegranates. Direct supplementation bypasses this limitation entirely.
Why this form
Selected as a direct postbiotic rather than relying on pomegranate extract, ensuring consistent delivery regardless of individual gut microbiome variation.
Naturally produced by gut bacteria from ellagitannins in pomegranates, walnuts, and certain berries. Supplemental form produced through precision fermentation.
Impacted hallmarks
Rhodiola Rosea
200 mg
What it does
Rhodiola rosea is an adaptogenic herb used for centuries to combat fatigue and improve stress resilience. It modulates the HPA axis, helping the body respond more efficiently to stress rather than masking fatigue with stimulation.
One of the primary feel-factor ingredients. Many users notice improvements in energy and clarity within the first week. Works synergistically with apigenin (Protect) for complementary stress resilience.
Why this form
Root extract standardized for active rosavins and salidroside, the compounds responsible for adaptogenic properties.
Extracted from the root of Rhodiola rosea, a succulent plant growing at high altitudes in arctic and mountainous regions of Europe and Asia.
Impacted hallmarks
Liposomal EGCG
80 mg
What it does
EGCG is the most studied polyphenol in green tea. It activates AMPK, a cellular energy sensor regulating metabolic balance, and supports antioxidant defense via the Nrf2 pathway.
Works synergistically with Rhodiola in the same capsule, combining metabolic signaling with adaptogenic resilience.
Why this form
Standard EGCG degrades rapidly in the gut with poor bioavailability. Liposomal encapsulation protects the compound through digestion and significantly improves absorption.
Primary catechin in green tea (Camellia sinensis). Liposomal delivery wraps the compound in a phospholipid layer that survives digestion.
Impacted hallmarks
B9 Folate (as 5-MTHF)
500 mcg
What it does
Folate is essential for one-carbon metabolism, DNA synthesis, and methylation. An estimated 40-60% of the population carries MTHFR gene variations that impair conversion of standard folic acid.
Paired with methylcobalamin in the same capsule, these two active B vitamins support the methylation cycle that NMN-to-NAD+ conversion depends on.
Why this form
Provided as 5-methyltetrahydrofolate calcium, the biologically active form. Bypasses the MTHFR conversion bottleneck, ensuring usable folate regardless of genetic background.
5-MTHF calcium is the crystalline calcium salt of the naturally occurring L-form of 5-methyltetrahydrofolic acid.
Impacted hallmarks
Vitamin B12 (Methylcobalamin)
200 mcg
What it does
B12 is required for myelin synthesis, red blood cell formation, and methionine metabolism. It works directly with folate in the methylation cycle regulating gene expression, detoxification, and neurotransmitter balance.
Particularly important for individuals with MTHFR variations where the methylation pathway is already under strain.
Why this form
Provided as methylcobalamin, the active coenzyme form. Standard cyanocobalamin must be converted and contains a cyanide molecule requiring detoxification. Methylcobalamin is directly usable.
Naturally occurring form of B12 found in animal-derived foods. Supplemental methylcobalamin produced through fermentation.
Impacted hallmarks
Vitamin D3
50 mcg (2000 IU)
What it does
Your body produces vitamin D3 naturally when ultraviolet light hits your skin. It is the only nutrient humans are designed to synthesize from sunlight. But modern indoor lifestyles mean most people no longer produce enough.
D3 functions more like a hormone than a vitamin, regulating over 1,000 genes. Deficiency affects an estimated 40% of U.S. adults.
Works in a four-ingredient synergy chain: magnesium (Core) activates D3, which increases calcium absorption from Ca-AKG (Core). K2 (Protect) then directs calcium to bones rather than soft tissue.
Why this form
Cholecalciferol from vegan lichen source. D3 raises serum levels more effectively than D2. Most D3 supplements use lanolin (sheep wool); ours is plant-based.
The human body synthesizes D3 from UVB sunlight exposure. Supplemental D3 is typically derived from lanolin (sheep wool). Ours is derived from lichen, a plant-based source, making it suitable for vegan diets.
Impacted hallmarks
PROTECT.
Shield Your Cells.
Feel: Calmer body • Smoother recovery • Resilient focus
DEFEND YOUR CELLS FROM STRESS & DECAY.
Daily stress, toxins, and inflammation age you faster than time. PROTECT switches on your body’s own defense systems, helping your cells stay resilient, focused, and calm under pressure.
Formula (Per Serving)
- Sulforaphane Activation Complex*Glucoraphanin (from broccoli seed) (140 mg)Myrosinase (from mustard seed) (35 mg)
- Maxicuma® (turmeric tetrahydrocurcuminoids) (100 mg)
- Dihydroberberine (from Berberis root) (100 mg)
- Spermidine Trihydrochloride (10 mg)
- Apigenin (from wild celery root) (50 mg)
- Lithium (as lithium orotate) (1 mg)
- Vitamin K2 (MK-7, all-trans) (150 mcg)
- BioPiperine® (Black pepper extract, Piper nigrum) (5 mg)
- Delayed Release, Acid-Resistant Vegan HPMC capsule
*Formulated with glucoraphanin and active myrosinase to support sulforaphane formation in the body. Delivered in acid-resistant capsules to help protect enzyme activity through the stomach.
Bioavailability architecture
Maxicuma curcumin paired with BioPerine because standard curcumin is notoriously poorly absorbed. Dihydroberberine selected over berberine for greater exposure at lower doses.
Sulforaphane activation system
Glucoraphanin paired with myrosinase so sulforaphane is generated in the body, rather than relying on an unstable preformed version.
Delayed-release design
Capsule engineered to slow stomach opening and reduce premature exposure for acid-sensitive ingredients like sulforaphane.
Protect Ingredients
The defense architecture. Reinforces anti-inflammatory signaling, metabolic regulation, autophagy, and Nrf2-mediated cellular defense.
2 delayed-release capsules per day
Curcumin (Meriva Phytosome)
100 mg
Phytosome-enhanced curcumin for broad anti-inflammatory support.
BioPerine (Piperine)
5 mg
Proven bioenhancer that increases absorption of multiple compounds.
Dihydroberberine
100 mg
Enhanced berberine for metabolic support with 5x better bioavailability.
Sulforaphane Activation Complex
Glucoraphanin 140 mg + Myrosinase 35 mg
Two-part system that generates fresh sulforaphane in your body on demand.
Apigenin
50 mg
Flavonoid that inhibits CD38 to preserve NAD+ levels.
Spermidine
10 mg
Autophagy activator that supports cellular recycling and renewal.
Vitamin K2 (MK-7, all-trans)
150 mcg
Directs calcium to bones and away from arteries and soft tissue.
Lithium Orotate
1 mg elemental
Trace-dose neuroprotective mineral for brain health and longevity.
Curcumin (Meriva Phytosome)
100 mg
What it does
Curcumin is the primary bioactive in turmeric and one of the most studied natural anti-inflammatory molecules. It modulates NF-kB, the master regulator of inflammatory gene expression.
When paired with BioPerine, curcumin absorption can increase by up to 2,000%.
Why this form
Standard curcumin is almost entirely destroyed during digestion. Meriva phytosome technology bonds curcumin to phospholipids, dramatically improving absorption. Further enhanced by BioPerine in the same capsule.
Extracted from the rhizome of Curcuma longa (turmeric), native to South and Southeast Asia. Meriva is a branded formulation by Indena.
Impacted hallmarks
BioPerine (Piperine)
5 mg
What it does
Piperine is the primary alkaloid in black pepper. It increases absorption by inhibiting glucuronidation, a liver process that rapidly clears beneficial compounds. The most documented interaction is with curcumin (up to 2,000% increase).
BioPerine functionally enhances absorption across the entire daily protocol, not just within this capsule.
Why this form
Patented, standardized extract guaranteed minimum 95% piperine. Standardization ensures consistent bioenhancer activity.
Extracted from the fruit of Piper nigrum (black pepper). BioPerine is a registered trademark of Sabinsa Corporation.
Impacted hallmarks
Dihydroberberine
100 mg
What it does
Berberine activates AMPK, the same metabolic sensor activated by exercise and caloric restriction. It supports healthy glucose metabolism, lipid balance, and cellular energy regulation.
Berberine also has well-documented effects on gut microbiome composition. Some researchers believe the microbiome interaction is a primary driver of its metabolic benefits.
Why this form
Dihydroberberine is berberine's active metabolite. Achieves up to 5x greater plasma levels at lower doses, eliminating the GI side effects that make standard berberine difficult to tolerate.
Berberine is found in goldenseal (Hydrastis canadensis), barberry (Berberis vulgaris), and Chinese goldthread (Coptis chinensis). Dihydroberberine is its reduced metabolite.
Impacted hallmarks
Sulforaphane Activation Complex
Glucoraphanin 140 mg + Myrosinase 35 mg
What it does
Sulforaphane is one of the most potent activators of Nrf2, the master switch for your body's antioxidant and detoxification defense system. But preformed sulforaphane is chemically reactive and degrades quickly. Most sulforaphane supplements contain broccoli extract with little actual sulforaphane left.
Instead of stabilizing an unstable molecule, we deliver the two components your body needs to generate sulforaphane itself. Glucoraphanin is the stable precursor. Myrosinase is the enzyme that converts it. When you take the capsule, the enzyme meets the precursor in your digestive tract and produces fresh sulforaphane on demand.
The Protect capsule uses a delayed-release design specifically to protect this system. Sulforaphane generation is more efficient in the intestinal environment. The delayed-release capsule slows stomach opening and reduces premature acid exposure, giving glucoraphanin and myrosinase the best conditions to do their work.
Why this form
Precursor-plus-enzyme approach is more reliable than attempting to stabilize preformed sulforaphane. Myrosinase sourced from mustard seed, one of the richest natural sources. Delayed-release capsule protects the system from stomach acid.
Glucoraphanin from broccoli seeds (Brassica oleracea). Myrosinase from mustard seed (Sinapis alba).
Impacted hallmarks
Apigenin
50 mg
What it does
Apigenin inhibits CD38, an enzyme that degrades NAD+. As we age, CD38 expression increases, accelerating NAD+ depletion. By inhibiting CD38, apigenin preserves the NAD+ that NMN (Energize) is working to restore.
NMN adds NAD+. Apigenin reduces the rate at which it is broken down. Together they support both sides of NAD biology across capsules.
Apigenin also has calming properties and supports healthy sleep architecture.
Why this form
Included specifically for CD38 inhibition, creating a direct synergy with NMN. Also supports downstream inflammatory modulation alongside Rhodiola.
Found in chamomile (Matricaria chamomilla), parsley (Petroselinum crispum), and celery (Apium graveolens).
Impacted hallmarks
Spermidine
10 mg
What it does
Spermidine is a naturally occurring polyamine that declines with age. It induces autophagy, the process by which cells clean up damaged proteins, organelles, and cellular debris.
One of the few natural compounds with epidemiological data linking higher dietary intake to reduced mortality. Emerging research connects it to gut barrier integrity and stem cell niche maintenance.
Why this form
Spermidine trihydrochloride provides a stable, bioavailable form of this naturally occurring polyamine at a meaningful dose.
Found in wheat germ, soybeans, aged cheese, mushrooms, and fermented foods. Produced through fermentation.
Impacted hallmarks
Vitamin K2 (MK-7, all-trans)
150 mcg
What it does
K2 activates osteocalcin (directs calcium into bones) and matrix GLA protein (prevents calcium depositing in arteries).
Completes the calcium utilization chain spanning Core and Protect: magnesium activates D3, D3 increases calcium absorption from Ca-AKG, and K2 ensures calcium goes where it should.
Why this form
MK-7 has a ~72 hour half-life vs a few hours for MK-4. All-trans isomer ensures maximum biological activity. Mixed-isomer products contain inactive cis-isomers.
Produced through bacterial fermentation from Bacillus subtilis natto.
Impacted hallmarks
Lithium Orotate
1 mg elemental
What it does
Lithium at trace doses (far below the psychiatric range of 300-1200 mg) is associated with neuroprotective effects. Populations with higher lithium in drinking water show lower rates of neurodegeneration.
At 1 mg, this is a nutritional trace dose (average daily intake from food/water is 0.6-3.1 mg). Supports GSK-3 beta inhibition and BDNF expression for brain health and neuroplasticity.
Why this form
Lithium orotate is lithium bonded to orotic acid. This is not the high-dose lithium carbonate used in psychiatric medicine.
Naturally occurring alkali metal found in trace amounts in drinking water, grains, and vegetables.
Impacted hallmarks
Cleanse.
Clear Damaged Cells.
Feel: Lightness • Smooth digestion • Cellular renewal
RESET YOUR CELLULAR LANDSCAPE.
Your body accumulates damaged cells that refuse to die. They linger, leak inflammatory signals, and drag down the tissue around them. CLEANSE is a monthly pulse designed to selectively clear these zombie cells, so your body can rebuild with a cleaner foundation.
Formula (Per Serving)
- Fisetin (Liposomal) (150 mg)
- Isoquercetin (150 mg)
- Bromelain 2400 GDU/g (micro encapsulated) (240 mg)
- Fenugreek Galactomannan (75 mg)
- BioPerine (Piperine) (2.5 mg)
- Vegan HPMC capsule with natural coloring
Targeted senescent cell clearance
Liposomal fisetin at 300mg is the most potent natural senolytic compound identified in published research, paired with isoquercetin for enhanced quercetin-class activity with superior absorption.
Enzymatic amplification
Bromelain provides proteolytic enzyme activity that supports the senolytic cascade and enhances the bioavailability of the flavonoid compounds.
Pulsed protocol, not daily
Taken as a 2-day consecutive dose once per month. Senolytic science supports intermittent clearance rather than chronic daily exposure, matching how senescent cells accumulate and how the immune system processes them.
Monthly Cleanse Ingredients
The senolytic pulse. A high-dose, short-duration protocol designed to selectively clear senescent cells.
2 capsules, 2 consecutive days per month
Fisetin (Liposomal)
300 mg
The most potent natural senolytic compound identified in published research.
Isoquercetin
150 mg
Highly absorbable quercetin-class flavonoid for enhanced senolytic support.
Bromelain
480 mg (2,400 GDU/g)
Proteolytic enzyme that amplifies the senolytic cascade.
Fenugreek Galactomannan
150 mg
Prebiotic fiber supporting sustained absorption and gut health.
BioPerine (Piperine)
5 mg
Enhances absorption of fisetin and isoquercetin during the pulse.
Fisetin (Liposomal)
300 mg
What it does
Fisetin was identified in a landmark Mayo Clinic screening as the most potent natural senolytic. It selectively targets senescent cells that release inflammatory SASP signals damaging surrounding tissue.
Senolytics are most effective in high-dose, short-duration pulses allowing concentrated clearance followed by immune system recovery.
Why this form
Standard fisetin has low oral bioavailability. Liposomal delivery protects the compound through digestion and enables effective concentrations during the pulse.
Found in strawberries, apples, persimmons, onions, and cucumbers. Strawberries have the highest dietary concentration.
Impacted hallmarks
Isoquercetin
150 mg
What it does
Isoquercetin is a glycoside form of quercetin. The dasatinib + quercetin combination pioneered at Mayo Clinic established quercetin's role in senescent cell clearance.
Paired with fisetin, it provides complementary quercetin-class senolytic activity through a more absorbable delivery path.
Why this form
Standard quercetin dihydrate has very poor water solubility. Isoquercetin as a glucoside has substantially better solubility and oral bioavailability.
Found in onions, apples, tarragon, and dill. Quercetin bonded to a glucose molecule for improved solubility.
Impacted hallmarks
Bromelain
480 mg (2,400 GDU/g)
What it does
Bromelain is a proteolytic enzyme complex that supports breakdown of cellular debris during senescent cell clearance and enhances bioavailability of the flavonoid compounds.
Well-documented anti-inflammatory properties help manage the transient inflammatory response when the immune system processes cleared senescent cells. 2,400 GDU/g is a standardized measure of enzymatic activity.
Why this form
Included for enzymatic amplification of the senolytic cascade and bioavailability support of fisetin and isoquercetin during the short pulse window.
Extracted from the stem of the pineapple plant (Ananas comosus). The stem contains much higher bromelain concentrations than the fruit.
Impacted hallmarks
Fenugreek Galactomannan
150 mg
What it does
A soluble polysaccharide fiber that slows release of active senolytic compounds, supporting sustained absorption rather than a single rapid spike.
Forms a viscous gel in the digestive tract that modulates absorption timing. As a prebiotic fiber, it also feeds beneficial gut bacteria, supporting microbiome health.
Why this form
Extends the effective exposure window through a different mechanism than piperine, providing complementary absorption support.
Extracted from seeds of fenugreek (Trigonella foenum-graecum), a legume native to the Mediterranean and South Asia.
Impacted hallmarks
BioPerine (Piperine)
5 mg
What it does
Piperine inhibits glucuronidation, extending the time fisetin and isoquercetin remain in circulation at effective concentrations.
During a short-duration pulse, maximizing the exposure window is critical. Piperine ensures the high-dose flavonoids reach their targets before liver clearance.
Why this form
BioPerine is a patented extract with minimum 95% piperine from Sabinsa Corporation.
Extracted from black pepper fruit (Piper nigrum).
Impacted hallmarks
THE MONTHLY CLEANSE
Clear the Cells That Slow You Down
Your body accumulates damaged cells that stop dividing but refuse to die. These senescent cells release inflammatory signals that accelerate aging in surrounding tissue. The Cleanse is designed to selectively clear them.
What are senescent cells?
When cells are damaged beyond repair, they enter a state called senescence. Instead of dying and being recycled, they persist. In small numbers, this is a normal defense mechanism.
The problem is accumulation. As we age, senescent cells build up and release a cocktail of inflammatory molecules called the SASP (senescence-associated secretory phenotype). This chronic low-grade inflammation damages neighboring cells and tissues, contributing to many of the conditions associated with aging.
Researchers call them zombie cells. They are not alive in any productive sense, but they are not dead either. And they make the neighborhood worse for everyone around them.
Senescent cell burden by decade
Accumulation accelerates as natural clearance mechanisms decline
Why pulsed, not daily
Not all senolytic strategies are equal. The timing and intensity of exposure matters as much as the compounds themselves.
No senolytic
Senescent cells accumulate unchecked. Their inflammatory signaling (SASP) spreads dysfunction to surrounding healthy tissue over time.
Burden rises continuously. No clearance mechanism.
Daily senolytic
Some protocols include senolytic compounds in their daily formula. Chronic low-dose exposure creates three problems: it can disrupt the temporary beneficial senescence your body uses for wound healing and tumor suppression, it builds cellular tolerance that blunts the clearance effect over time, and it never reaches the concentration threshold needed to trigger selective apoptosis in damaged cells.
Sub-therapeutic exposure. Tolerance builds. Clearance effect weakens over time.
Pulsed senolytic
High-dose, short-duration exposure on a monthly schedule. Concentrated clearance allows the immune system to process and remove senescent cells between doses, then recovers fully before the next pulse.
Periodic clearance creates a sawtooth pattern. Burden stays low over time.
Recommended pulse frequency
Senescent cell burden increases with age. Your optimal pulse frequency depends on where you are in that curve.
30s
years old
1x monthly
2 sachets, 2 consecutive days
Senescent cell burden is low but beginning to accumulate. Monthly clearance serves as preventive maintenance to stay ahead of the curve.
Included in protocol40s
years old
1-2x monthly
2-4 sachets per month
Accumulation accelerates as natural immune clearance begins to slow. This is the inflection point where additional pulses can make the most meaningful difference.
1 included + 1 optional add-on pulse pack recommended50+
years old
2-3x monthly
4-6 sachets per month
Significant senescent cell burden. Natural clearance mechanisms are substantially diminished. More frequent pulsing supports a more aggressive clearance schedule.
1 included + 2 add-on pulse packs recommendedADDITIONAL PULSE PACKS
Add pulses based on your needs
Every TimeWarp protocol includes one monthly cleanse. For those who want a more aggressive clearance schedule, additional pulse packs are available to add at checkout. Each pack contains 2 sachets for one additional 2-day pulse.
Additional pulse packs are only available with an active TimeWarp protocol subscription.
Available as an add-on at checkout
FORMULATION INTELLIGENCE
How the System Works Together
Every ingredient was selected not just for individual efficacy, but for how it interacts with the rest of the protocol. Bioavailability, synergy, and molecular form were treated as core design variables.
01
Bioavailability upgrades
Every delivery form was chosen to maximize what your body actually absorbs. A compound that is poorly absorbed is biologically irrelevant, regardless of mechanistic promise.
"Bioavailability was treated as a core design variable, not an afterthought."
Dr. Stefanie Morgan
Clinical Geroscience, Science Advisory Board
Liposomal EGCG
Maxicuma curcumin + BioPerine
Dihydroberberine over berberine
Glucoraphanin + myrosinase
Liposomal fisetin
Chelated magnesium (bisglycinate)
Active B vitamins (P-5-P, 5-MTHF, methylcobalamin)
Vitamin D3 as cholecalciferol
Vitamin K2 as MK-7 (all-trans)
02
Cross-pill synergies
Ingredients across different capsules were chosen to amplify each other. The protocol works as an integrated system, not isolated compounds.
"Most approaches to longevity focus on single pathways. But aging does not work that way. It emerges from interactions across biological systems, where the hallmarks influence and reinforce each other."
Dr. David Furman
Immunology & Systems Biology, Science Advisory Board
NMN + Pterostilbene
Curcumin + BioPerine (system-wide)
5-MTHF + methylcobalamin + Ca-AKG
Rhodiola + Apigenin
D3 + K2 (MK-7)
Fisetin + isoquercetin + bromelain
03
Form selection philosophy
In every case where a superior molecular form exists, we chose it. These are harder sourcing decisions that most companies avoid because the upgraded forms cost more.
"A compound that is poorly absorbed is biologically irrelevant, regardless of mechanistic promise."
Dr. Deepti Agarwal
Clinical Longevity & Precision Medicine, Science Advisory Board
Pterostilbene over resveratrol
Dihydroberberine over berberine HCl
Glucoraphanin + myrosinase over preformed sulforaphane
Ca-AKG over AAKG
Isoquercetin over quercetin
Beta-NMN as the NAD precursor
THE FORMULA
24 Ingredients. Zero Compromises.
Every ingredient earned its place through mechanistic evidence, human data, and synergy analysis.
Ca-AKG
1000 mg
Supports cellular energy metabolism and epigenetic regulation.
Pterostilbene
50 mg
Activates sirtuins for cellular defense and DNA repair.
Cycloastragenol
20 mg
Supports telomere maintenance via telomerase activation.
Magnesium Bisglycinate
200 mg
Essential cofactor for 300+ enzymatic reactions and sleep quality.
Vitamin B6 (P-5-P)
10 mg
Active coenzyme form supporting methylation and amino acid metabolism.
Beta-NMN
350 mg
Direct NAD+ precursor for cellular energy production.
Urolithin A
500 mg
Triggers mitophagy to clear and renew damaged mitochondria.
Rhodiola Rosea
200 mg
Adaptogenic support for stress resilience, energy, and focus.
Liposomal EGCG
80 mg
Bioavailability-enhanced green tea extract for metabolic and antioxidant support.
Vitamin B9 Folate (5-MTHF)
500 mcg
Active methylfolate that bypasses the MTHFR conversion step.
Vitamin B12 (Methylcobalamin)
200 mcg
Active coenzyme B12 for methylation and neurological function.
Vitamin D3
50 mcg (2000 IU)
Supports immune regulation, bone health, and calcium metabolism.
Curcumin (Meriva)
100 mg
Phytosome-enhanced curcumin for broad anti-inflammatory support.
BioPerine (Piperine)
5 mg
Proven bioenhancer that increases absorption of multiple compounds.
Dihydroberberine
100 mg
Enhanced berberine for metabolic support with 5x better bioavailability.
Sulforaphane Activation Complex
Glucoraphanin 140mg + Myrosinase 35mg
Two-part system generating fresh sulforaphane on demand.
Apigenin
50 mg
Flavonoid that inhibits CD38 to preserve NAD+ levels.
Spermidine
10 mg
Autophagy activator that supports cellular recycling and renewal.
Vitamin K2 (MK-7)
150 mcg
Directs calcium to bones and away from arteries.
Lithium Orotate
1 mg elemental
Trace-dose neuroprotective mineral for brain health.
Fisetin (Liposomal)
300 mg
Most potent natural senolytic identified in published research.
Isoquercetin
150 mg
Highly absorbable quercetin-class senolytic support.
Bromelain
480 mg (2,400 GDU/g)
Proteolytic enzyme amplifying the senolytic cascade.
Fenugreek Galactomannan
150 mg
Prebiotic fiber supporting sustained absorption and gut health.
BioPerine (Piperine)
5 mg
Enhances absorption of fisetin and isoquercetin during the pulse.
Ca-AKG
1000 mg
What it does
Alpha-ketoglutarate is central to the Krebs cycle and serves as a cofactor for DNA demethylation enzymes, connecting metabolism directly to epigenetic regulation.
Circulating AKG levels decline with age. Ca-AKG restores AKG in a stable, longevity-oriented calcium salt form.
Why this form
Delivers AKG directly in a calcium salt form rather than the arginine blend (AAKG) used in sports nutrition.
Produced naturally by every cell as part of the citric acid cycle. Supplemental Ca-AKG produced through chemical synthesis.
Impacted hallmarks
Pterostilbene
50 mg
What it does
A polyphenol from blueberries with 4x higher bioavailability than resveratrol. Activates SIRT1, involved in DNA repair, mitochondrial function, and cellular stress resistance.
Why this form
Selected over resveratrol for 4x higher bioavailability and superior metabolic stability.
Found in blueberries (Vaccinium spp.), grapes, and the heartwood of the Indian kino tree.
Impacted hallmarks
Cycloastragenol
20 mg
What it does
A triterpenoid saponin from Astragalus membranaceus. One of a small number of compounds shown to activate telomerase, the enzyme maintaining telomere length.
Why this form
A rare compound adding differentiated telomere-biology support uncommon in daily longevity formulas.
Extracted from the root of Astragalus membranaceus, native to northern China and Mongolia.
Impacted hallmarks
Magnesium Bisglycinate
200 mg
What it does
Involved in over 300 enzymatic reactions. An estimated 50% of adults do not meet adequate intake. Also activates vitamin D3 (Energize), creating cross-protocol synergy.
Why this form
Chelated form for superior absorption. Magnesium oxide has roughly 4% bioavailability. Bisglycinate absorbs significantly better with fewer GI issues.
Magnesium bonded to two molecules of glycine. Chelation protects the mineral through digestion.
Impacted hallmarks
Vitamin B6 (P-5-P)
10 mg
What it does
Involved in 100+ enzyme reactions. Essential for nervous and immune system function. Relevant for MTHFR gene variation carriers.
Why this form
Found naturally in potatoes, bananas, chickpeas, poultry, and fish. Potatoes are one of the richest whole-food sources of B6. Supplemental P-5-P is the pre-activated coenzyme form, manufactured to provide the active metabolite directly without requiring liver conversion.
P-5-P is the active metabolite of vitamin B6. Supplemental P-5-P is manufactured to provide the coenzyme directly. B6 is one of the most common micronutrient gaps in the modern diet, despite being abundant in everyday foods like potatoes and bananas.
Impacted hallmarks
Beta-NMN
350 mg
What it does
Direct precursor to NAD+, required for hundreds of metabolic reactions. NAD+ declines significantly with age. NMN is one enzymatic step from NAD+.
The conversion consumes methyl groups, paired with 5-MTHF and methylcobalamin in the same capsule to replenish them.
Why this form
Selected over NR, niacin, and NAD+ for direct conversion pathway and growing human clinical data. Beta-NMN is the bioactive isomer.
Occurs naturally in broccoli, cabbage, avocado, and edamame. Produced through enzymatic biosynthesis.
Impacted hallmarks
Urolithin A
500 mg
What it does
Triggers mitophagy to recycle damaged mitochondria. Only ~40% of people produce it naturally from pomegranates. Direct supplementation bypasses gut microbiome variability.
Why this form
Direct postbiotic rather than pomegranate extract. Consistent delivery regardless of individual gut microbiome.
Produced by gut bacteria from ellagitannins in pomegranates. Supplemental form via precision fermentation.
Impacted hallmarks
Rhodiola Rosea
200 mg
What it does
Adaptogenic herb modulating the HPA axis for efficient stress response. Primary feel-factor ingredient. Synergizes with apigenin (Protect) for complementary stress resilience.
Why this form
Root extract standardized for rosavins and salidroside.
Root of Rhodiola rosea, growing at high altitudes in arctic regions of Europe and Asia.
Impacted hallmarks
Liposomal EGCG
80 mg
What it does
Most studied green tea polyphenol. Activates AMPK and Nrf2 pathway. Synergizes with Rhodiola in the same capsule.
Why this form
Standard EGCG degrades rapidly in the gut. Liposomal encapsulation protects through digestion and improves absorption.
Primary catechin in green tea (Camellia sinensis). Liposomal phospholipid delivery.
Impacted hallmarks
Vitamin B9 Folate (5-MTHF)
500 mcg
What it does
Essential for methylation, DNA synthesis. 40-60% of people carry MTHFR variations impairing folic acid conversion. Paired with B12 to support the methylation cycle NMN depends on.
Why this form
5-methyltetrahydrofolate calcium bypasses the MTHFR bottleneck. Directly usable regardless of genetics.
Crystalline calcium salt of the naturally occurring L-form of 5-methyltetrahydrofolic acid.
Impacted hallmarks
Vitamin B12 (Methylcobalamin)
200 mcg
What it does
Required for myelin synthesis, red blood cells, and methionine metabolism. Works with folate in the methylation cycle. Critical for MTHFR carriers.
Why this form
Active coenzyme form. Standard cyanocobalamin requires conversion and contains cyanide requiring detoxification.
Naturally occurring B12 form. Supplemental form produced through fermentation.
Impacted hallmarks
Vitamin D3
50 mcg (2000 IU)
What it does
Your body produces vitamin D3 naturally when ultraviolet light hits your skin. It is the only nutrient humans are designed to synthesize from sunlight. But modern indoor lifestyles mean most people no longer produce enough.
D3 functions more like a hormone than a vitamin, regulating over 1,000 genes. Deficiency affects an estimated 40% of U.S. adults.
Works in a four-ingredient synergy chain: magnesium (Core) activates D3, which increases calcium absorption from Ca-AKG (Core). K2 (Protect) then directs calcium to bones rather than soft tissue.
Why this form
Cholecalciferol from vegan lichen. Raises serum levels more effectively than D2. Plant-based source.
Derived from lichen. Suitable for vegan diets.
Impacted hallmarks
Curcumin (Meriva)
100 mg
What it does
Primary turmeric bioactive. Modulates NF-kB inflammatory gene expression. With BioPerine, absorption increases up to 2,000%.
Why this form
Meriva phytosome bonds curcumin to phospholipids. Standard curcumin is almost entirely destroyed during digestion.
Rhizome of Curcuma longa (turmeric), native to South and Southeast Asia. Meriva by Indena.
Impacted hallmarks
BioPerine (Piperine)
5 mg
What it does
Inhibits glucuronidation, extending compound circulation time. Enhances absorption across the entire protocol, not just this capsule.
Why this form
Patented extract, minimum 95% piperine. Consistent bioenhancer activity.
Fruit of Piper nigrum (black pepper). BioPerine by Sabinsa Corporation.
Impacted hallmarks
Dihydroberberine
100 mg
What it does
Activates AMPK for metabolic regulation. Well-documented gut microbiome effects may be a primary driver of metabolic benefits.
Why this form
Active metabolite achieving 5x greater plasma levels at lower doses, eliminating GI side effects of standard berberine.
Found in goldenseal, barberry, and Chinese goldthread. Dihydroberberine is the reduced metabolite.
Impacted hallmarks
Sulforaphane Activation Complex
Glucoraphanin 140mg + Myrosinase 35mg
What it does
Sulforaphane is one of the most potent Nrf2 activators. Instead of unstable preformed sulforaphane, we deliver the precursor plus the enzyme. They meet in your digestive tract and generate fresh sulforaphane on demand.
Delayed-release capsule protects the system from stomach acid for optimal intestinal conversion.
Why this form
Precursor-plus-enzyme is more reliable than preformed sulforaphane. Myrosinase from mustard seed. Delayed-release capsule protects from stomach acid.
Glucoraphanin from broccoli seeds (Brassica oleracea). Myrosinase from mustard seed (Sinapis alba).
Impacted hallmarks
Apigenin
50 mg
What it does
Inhibits CD38, the enzyme degrading NAD+. NMN (Energize) adds NAD+. Apigenin reduces the rate it breaks down. Together they support both sides of NAD biology. Also supports healthy sleep.
Why this form
Included specifically for CD38 inhibition synergy with NMN. Also supports stress resilience alongside Rhodiola.
Found in chamomile, parsley, and celery.
Impacted hallmarks
Spermidine
10 mg
What it does
Induces autophagy for cellular cleanup. One of few compounds with epidemiological mortality data. Emerging links to gut barrier integrity and stem cell maintenance.
Why this form
Spermidine trihydrochloride for stable, bioavailable delivery at a meaningful dose.
Found in wheat germ, soybeans, aged cheese, mushrooms. Produced through fermentation.
Impacted hallmarks
Vitamin K2 (MK-7)
150 mcg
What it does
Activates osteocalcin (calcium to bones) and matrix GLA protein (prevents arterial calcification). Completes the calcium chain with magnesium, D3, and Ca-AKG.
Why this form
MK-7 has ~72 hour half-life vs hours for MK-4. All-trans isomer for maximum activity.
Bacterial fermentation from Bacillus subtilis natto.
Impacted hallmarks
Lithium Orotate
1 mg elemental
What it does
Trace doses associated with neuroprotection. Supports GSK-3 beta inhibition and BDNF expression. At 1 mg, this is nutritional (average intake from food/water: 0.6-3.1 mg).
Why this form
Lithium orotate (lithium bonded to orotic acid). Not the high-dose lithium carbonate used in psychiatry.
Naturally occurring alkali metal in drinking water, grains, and vegetables.
Impacted hallmarks
Fisetin (Liposomal)
300 mg
What it does
Identified at Mayo Clinic as the most potent natural senolytic. Selectively targets senescent cells releasing inflammatory SASP. Most effective in high-dose, short-duration pulses.
Why this form
Liposomal delivery overcomes low native bioavailability for effective pulse concentrations.
Found in strawberries, apples, persimmons, onions, cucumbers.
Impacted hallmarks
Isoquercetin
150 mg
What it does
Glycoside form of quercetin. Provides complementary quercetin-class senolytic activity paired with fisetin through a more absorbable path.
Why this form
Standard quercetin has poor solubility. Isoquercetin as a glucoside has substantially better absorption.
Found in onions, apples, tarragon, dill. Quercetin bonded to glucose for solubility.
Impacted hallmarks
Bromelain
480 mg (2,400 GDU/g)
What it does
Supports breakdown of cellular debris during senescent cell clearance. Anti-inflammatory properties help manage the transient response during immune processing.
Why this form
Enzymatic amplification of the senolytic cascade plus bioavailability support for flavonoid compounds.
Stem of the pineapple plant (Ananas comosus). Higher concentration than the fruit.
Impacted hallmarks
Fenugreek Galactomannan
150 mg
What it does
Soluble fiber slowing release of senolytic compounds for sustained absorption. Also feeds beneficial gut bacteria as a prebiotic.
Why this form
Extends exposure window through a different mechanism than piperine. Complementary absorption support.
Seeds of fenugreek (Trigonella foenum-graecum), a legume native to the Mediterranean.
Impacted hallmarks
BioPerine (Piperine)
5 mg
What it does
Extends circulation time of fisetin and isoquercetin by inhibiting glucuronidation. Maximizes exposure during the short pulse window.
Why this form
Patented extract, minimum 95% piperine by Sabinsa Corporation.
Black pepper fruit (Piper nigrum).
Impacted hallmarks
