01
Chelated magnesium
Core uses magnesium bisglycinate, a chelated form selected for tolerability and favorable absorption characteristics.
THE FORMULA
Meet Protocol 01
Each capsule engineered to target aging at its root: together they cover all 12 Hallmarks of Aging.
The TimeWarp Protocol
DESIGNED FOR MAXIMUM IMPACT.
dive deep into each capsule
Capsule Deep Dive
CORE.
rebuild your cellular engine.
feel: steady energy • Improved focus • Foundational vitality
RESTORE YOUR BIOLOGICAL FOUNDATION.
You start the day depleted. CORE restores your cellular engine. It rebuilds the energy cycle, supports healthy DNA expression, and reinforces the foundational processes your cells rely on every day.
Formula (Per Serving)
- Calcium Alpha-Ketoglutarate (1000 mg)
- Pterostilbene (50 mg)
- Cycloastragenol (10 mg)
- Vitamin B6 (as pyridoxal-5-phosphate) (10 mg)
- Magnesium Bisglycinate (200 mg)
- Vegan HPMC capsule with natural coloring
CORE
Formulation highlights
02
Pterostilbene by design
Pterostilbene was selected for its metabolic stability and oral bioavailability characteristics.
03
Telomere-biology component
Cycloastragenol gives Core a dedicated ingredient studied in telomere biology within the broader Hallmarks-based formulation.
Core
Core Ingredients
The metabolic foundation. Restores cellular energy infrastructure, enzymatic function, and telomere-aligned longevity biology.
2 capsules per day
Calcium Alpha-Ketoglutarate (Ca-AKG)
1000 mg
Supports cellular energy metabolism and epigenetic regulation.
Learn more
Pterostilbene
50 mg
Supports sirtuin signaling, a pathway tied to cellular defense and DNA repair.
Learn more
Cycloastragenol
10 mg
Supports telomere biology, one of the twelve hallmarks of aging.
Learn more
Magnesium Bisglycinate
200 mg
Essential cofactor for 300+ enzymatic reactions and sleep quality.
Learn more
Vitamin B6 (as P-5-P)
10 mg
Active coenzyme form supporting methylation and amino acid metabolism.
Learn more
Core
Calcium Alpha-Ketoglutarate (Ca-AKG)
1000 mg
What it does
Alpha-ketoglutarate is a naturally occurring molecule central to the Krebs cycle, the metabolic process your cells use to produce energy. It also serves as a cofactor for enzymes involved in DNA demethylation, connecting cellular metabolism directly to epigenetic regulation.
As we age, circulating AKG levels decline. Supplementing with calcium alpha-ketoglutarate restores AKG in a stable, longevity-oriented calcium salt form.
Why this form
Ca-AKG delivers alpha-ketoglutarate directly in a calcium salt form, without relying on the arginine blend (AAKG) commonly used in sports nutrition. This is a longevity-oriented delivery, not a performance-oriented one.
AKG is produced naturally by every cell in the human body as part of the citric acid cycle. Supplemental Ca-AKG is produced through chemical synthesis.
Hallmark context
Core
Pterostilbene
50 mg
What it does
Pterostilbene is a polyphenol found naturally in blueberries. It belongs to the same family as resveratrol but shows roughly 4x the oral bioavailability of resveratrol in published pharmacokinetic studies, along with a significantly longer half-life, meaning more of the compound reaches your cells and stays active longer.
Pterostilbene supports sirtuin proteins (particularly SIRT1), a family of enzymes involved in DNA repair, mitochondrial function, and cellular stress resistance. These are the same pathways engaged by caloric restriction.
Why this form
Selected over the more well-known resveratrol for its superior metabolic stability and roughly 4x the oral bioavailability. Resveratrol is more famous. Pterostilbene is better built to survive digestion.
Found naturally in blueberries (Vaccinium spp.), grapes, and the heartwood of the Indian kino tree (Pterocarpus marsupium).
Hallmark context
Core
Cycloastragenol
10 mg
What it does
Cycloastragenol is a triterpenoid saponin derived from Astragalus membranaceus, a plant with a long history in traditional Chinese medicine. It is one of a small number of compounds studied for its role in telomere biology. Telomeres are protective caps at the ends of chromosomes that shorten with each cell division. When they become critically short, cells enter senescence or die.
Why this form
A rare and specialized compound that adds a differentiated telomere-biology component uncommon in most daily longevity formulas.
Extracted from the root of Astragalus membranaceus, a perennial plant native to northern China and Mongolia.
Hallmark context
Core
Magnesium Bisglycinate
200 mg
What it does
Magnesium is involved in over 300 enzymatic reactions including energy production, DNA synthesis, protein folding, and nervous system regulation. An estimated 50% of adults do not meet adequate intake levels.
Magnesium also plays a critical role in activating vitamin D3 (in the Energize capsule), creating a functional synergy across the protocol.
Why this form
Bisglycinate (chelated) form selected for superior absorption and tolerability. Magnesium oxide, the most common form, has roughly 4% bioavailability. Bisglycinate absorbs significantly better with fewer GI issues.
Magnesium bonded to two molecules of glycine, an amino acid. The chelation protects the mineral through digestion.
Hallmark context
Core
Vitamin B6 (as P-5-P)
10 mg
What it does
Vitamin B6 is involved in over 100 enzyme reactions related to amino acid metabolism, neurotransmitter synthesis, and methylation pathways. It is essential for nervous and immune system function.
Particularly relevant for individuals with MTHFR gene variations that impair B-vitamin conversion.
Why this form
Found naturally in potatoes, bananas, chickpeas, poultry, and fish. Potatoes are one of the richest whole-food sources of B6. Supplemental P-5-P is the pre-activated coenzyme form, manufactured to provide the active metabolite directly without requiring liver conversion.
P-5-P is the active metabolite of vitamin B6. Supplemental P-5-P is manufactured to provide the coenzyme directly. B6 is one of the most common micronutrient gaps in the modern diet, despite being abundant in everyday foods like potatoes and bananas.
Hallmark context
ENERGIZE.
Reignite Your Cellular Power.
Feel: All-day energy • Clear mind • Elevated performance
POWER YOUR CELLS.
When your cells slow down, so does your energy, focus, and mood. ENERGIZE reignites your mitochondria, the power plants of your cells, so you feel steady, alert, and alive all day.
Formula (Per Serving)
- Urolithin A (500 mg)
- NAD+ Support Complex:
- -- Nicotinamide mononucleotide (NMN) (350 mg)
- -- Apigenin (from celery root) (50 mg)
- EGCG (Liposomal, from green tea leaf extract) (80 mg)
- Rhodiola (from Rhodiola rosea root) (200 mg)
- Vitamin B9 (Folate as 5-MTHF, L-methylfolate) (0.5 mg)
- Vitamin B12 (as Methylcobalamin) (0.2 mg)
- Vitamin D3 (as Cholecalciferol from algae) (0.05 mg)
- Vegan HPMC capsule with natural coloring
ENERGIZE
Formulation highlights
01
Active methylation pair
5-MTHF and methylcobalamin are paired to support normal one-carbon metabolism and methylation.
02
Urolithin A, provided directly
Urolithin A is provided directly rather than relying on individual gut conversion from dietary ellagitannin precursors.
03
Liposomal EGCG
EGCG is delivered in a liposomal format selected to support dispersibility and bioavailability.
Energize
Energize Ingredients
The cellular engine. Supports NAD metabolism, mitochondrial renewal, methylation, and day-to-day resilience.
2 capsules per day
Urolithin A
500 mg
A postbiotic metabolite studied for muscle health and healthy aging.
Learn more
Beta-NMN
350 mg
Direct NAD+ precursor for cellular energy production.
Learn more
Apigenin
50 mg
Flavonoid that inhibits CD38 to preserve NAD+ levels.
Learn more
Rhodiola Rosea
200 mg
Adaptogenic support for stress resilience, energy, and focus.
Learn more
Liposomal EGCG
80 mg
Bioavailability-enhanced green tea extract for metabolic and antioxidant support.
Learn more
B9 Folate (as 5-MTHF)
500 mcg
Active methylfolate that bypasses the MTHFR conversion step.
Learn more
Vitamin B12 (Methylcobalamin)
200 mcg
Active coenzyme B12 for methylation and neurological function.
Learn more
Vitamin D3
50 mcg (2000 IU)
Supports immune regulation, bone health, and calcium metabolism.
Learn more
Energize
Urolithin A
500 mg
What it does
Urolithin A is a postbiotic metabolite that some gut microbiomes produce from ellagitannins found in foods such as pomegranates, walnuts, and certain berries. Direct supplementation provides a defined amount without relying on individual conversion from dietary precursors.
Why this form
Provided as urolithin A directly rather than as an ellagitannin precursor, giving a defined amount per serving independent of individual gut conversion.
Urolithin A is a gut-derived metabolite of ellagitannins found in pomegranates and other plant foods.
Hallmark context
Energize
Beta-NMN
350 mg
What it does
NMN is a nucleotide that serves as a direct precursor to NAD+, one of the most critical molecules in human biology. NAD+ is required for hundreds of metabolic reactions including mitochondrial energy production, DNA repair, and sirtuin activation.
NAD+ levels decline significantly with age. By your 50s, circulating NAD+ may be half of what it was in your 20s.
The NMN-to-NAD+ conversion consumes methyl groups, which is why we paired it with 5-MTHF and methylcobalamin in the same capsule to replenish what gets used.
Why this form
Selected over NR, niacin, and NAD+ itself for its direct conversion pathway (one enzymatic step from NAD+) and growing body of human clinical data. Beta-NMN is the bioactive isomer.
Occurs naturally in small amounts in broccoli, cabbage, avocado, and edamame. Supplemental NMN is produced through enzymatic biosynthesis.
Hallmark context
Energize
Apigenin
50 mg
What it does
DescriptioApigenin inhibits CD38, an enzyme that degrades NAD+. As we age, CD38 expression increases, accelerating NAD+ depletion. By inhibiting CD38, apigenin preserves the NAD+ that NMN (Energize) is working to restore.
NMN adds NAD+. Apigenin reduces the rate at which it is broken down. Together they support both sides of NAD biology across capsules.
Apigenin also has calming properties and supports healthy sleep architecture.n.
Why this form
Included specifically for CD38 inhibition, creating a direct synergy with NMN. Also supports downstream inflammatory modulation alongside Rhodiola.
Found in chamomile (Matricaria chamomilla), parsley (Petroselinum crispum), and celery (Apium graveolens).
Hallmark context
Energize
Rhodiola Rosea
200 mg
What it does
Rhodiola rosea is an adaptogenic herb used for centuries to combat fatigue and improve stress resilience. It modulates the HPA axis, helping the body respond more efficiently to stress rather than masking fatigue with stimulation.
One of the primary feel-factor ingredients. Works synergistically with apigenin for complementary stress resilience.
Why this form
Root extract standardized for active rosavins and salidroside, the compounds responsible for adaptogenic properties.
Extracted from the root of Rhodiola rosea, a succulent plant growing at high altitudes in arctic and mountainous regions of Europe and Asia.
Hallmark context
Energize
Liposomal EGCG
80 mg
What it does
EGCG is the most studied polyphenol in green tea. It activates AMPK, a cellular energy sensor regulating metabolic balance, and supports antioxidant defense via the Nrf2 pathway.
Works synergistically with Rhodiola in the same capsule, combining metabolic signaling with adaptogenic resilience.
Why this form
Standard EGCG degrades rapidly in the gut with poor bioavailability. Liposomal encapsulation protects the compound through digestion and significantly improves absorption.
Primary catechin in green tea (Camellia sinensis). Liposomal delivery wraps the compound in a phospholipid layer that survives digestion.
Hallmark context
Energize
B9 Folate (as 5-MTHF)
500 mcg
What it does
Folate is essential for one-carbon metabolism, DNA synthesis, and methylation. An estimated 40-60% of the population carries MTHFR gene variations that impair conversion of standard folic acid.
Paired with methylcobalamin in the same capsule, these two active B vitamins support the methylation cycle that NMN-to-NAD+ conversion depends on.
Why this form
Provided as 5-methyltetrahydrofolate calcium, the biologically active form. Bypasses the MTHFR conversion bottleneck, ensuring usable folate regardless of genetic background.
5-MTHF calcium is the crystalline calcium salt of the naturally occurring L-form of 5-methyltetrahydrofolic acid.
Hallmark context
Energize
Vitamin B12 (Methylcobalamin)
200 mcg
What it does
B12 is required for myelin synthesis, red blood cell formation, and methionine metabolism. It works directly with folate in the methylation cycle regulating gene expression, detoxification, and neurotransmitter balance.
Particularly important for individuals with MTHFR variations where the methylation pathway is already under strain.
Why this form
Provided as methylcobalamin, the active coenzyme form. Standard cyanocobalamin must be converted and contains a cyanide molecule requiring detoxification. Methylcobalamin is directly usable.
Naturally occurring form of B12 found in animal-derived foods. Supplemental methylcobalamin produced through fermentation.
Hallmark context
Energize
Vitamin D3
50 mcg (2000 IU)
What it does
Your body produces vitamin D3 naturally when ultraviolet light hits your skin. It is the only nutrient humans are designed to synthesize from sunlight. But modern indoor lifestyles mean most people no longer produce enough.
D3 functions more like a hormone than a vitamin, regulating over 1,000 genes. Deficiency affects an estimated 40% of U.S. adults.
Works in a four-ingredient synergy chain: magnesium (Core) activates D3, which increases calcium absorption from Ca-AKG (Core). K2 (Protect) then directs calcium to bones rather than soft tissue.
Why this form
Cholecalciferol from vegan lichen source. D3 raises serum levels more effectively than D2. Most D3 supplements use lanolin (sheep wool); ours is plant-based.
The human body synthesizes D3 from UVB sunlight exposure. Supplemental D3 is typically derived from lanolin (sheep wool). Ours is derived from lichen, a plant-based source, making it suitable for vegan diets.
Hallmark context
PROTECT.
Shield Your Cells.
Feel: Calmer body • Smoother recovery • Resilient focus
DEFEND YOUR CELLS FROM STRESS & DECAY.
Daily stress, toxins, and inflammation age you faster than time. PROTECT switches on your body’s own defense systems, helping your cells stay resilient, focused, and calm under pressure.
Formula (Per Serving)
- Sulforaphane Activation Complex*:
- -- Glucoraphanin (from broccoli seed) (70 mg)
- -- Myrosinase (from mustard seed) (50 mg)
- -- Sodium Ascorbate (65 mg)
- Curcumin (liposomal, from Curcuma longa) (150 mg)
- Dihydroberberine (from Berberis root) (100 mg)
- Spermidine (as trihydrochloride) (10 mg)
- Vitamin K2 (MK-7, all-trans) (150 mcg)
- Piperine (from Piper nigrum fruit) (5 mg)
- Delayed Release Acid-Resistant Vegan HPMC capsule
*Sulforaphane is formulated with glucoraphanin, active myrosinase and sodium ascorbate to support sulforaphane formation in the body. Delivered in acid-resistant capsules to help protect enzyme activity through the stomach. Yields ~10-15 mg Sulforaphane.
PROTECT
Formulation highlights
01
Sulforaphane formation system
Glucoraphanin, myrosinase, and sodium ascorbate are combined in a system designed to support sulforaphane formation after ingestion.
02
Delayed-release design
The Protect capsule uses delayed-release delivery around the glucoraphanin and myrosinase system.
03
Curcumin + piperine
Liposomal curcumin is paired with piperine with bioavailability in mind.
Protect
Protect Ingredients
Supports a healthy inflammatory response
2 delayed-release capsules per day
Liposomal Curcumin
150 mg
Liposomal curcumin, selected to support a healthy inflammatory response.
Learn more
Sulforaphane Activation Complex
Glucoraphanin 70 mg + Myrosinase 50 mg + Sodium Ascorbate 65 mg (Yields ~10-15 mg sulforaphane)
4-part system (including delayed release capsule) that generates fresh sulforaphane in your body on demand.
Learn more
Dihydroberberine
100 mg
Enhanced berberine, selected for roughly 5x the absorption of standard berberine at a lower dose.
Learn more
Spermidine
10 mg
A naturally occurring polyamine studied for its role in autophagy and cellular recycling.
Learn more
Vitamin K2 (MK-7, all-trans)
150 mcg
Directs calcium to bones and away from arteries and soft tissue.
Learn more
Piperine
5 mg
Black pepper extract, included to support absorption of other compounds.
Learn more
Protect
Liposomal Curcumin
150 mg
What it does
Curcumin is the primary bioactive in turmeric and one of the most studied plant compounds in inflammation research. It modulates NF-kB, a master regulator of inflammatory gene expression.
Why this form
Standard curcumin has low oral bioavailability. Liposomal delivery was selected to improve its formulation and absorption characteristics.
Extracted from the rhizome of Curcuma longa (turmeric), native to South and Southeast Asia.
Hallmark context
Protect
Sulforaphane Activation Complex
Glucoraphanin 70 mg + Myrosinase 50 mg + Sodium Ascorbate 65 mg (Yields ~10-15 mg sulforaphane)
What it does
Sulforaphane is one of the most potent activators of Nrf2, the master switch for your body's antioxidant and detoxification defense system. But preformed sulforaphane is chemically reactive and degrades quickly. Preformed sulforaphane is chemically reactive and can present stability challenges in finished supplements.
Instead of stabilizing an unstable molecule, we deliver the two components your body needs to generate sulforaphane itself. Glucoraphanin is the stable precursor. Myrosinase is the enzyme that converts it. When you take the capsule, the enzyme meets the precursor in your digestive tract and produces fresh sulforaphane on demand.
The Protect capsule uses a delayed-release design specifically to protect this system. Sulforaphane generation is more efficient in the intestinal environment. The delayed-release capsule slows stomach opening and reduces premature acid exposure, giving glucoraphanin and myrosinase the best conditions to do their work.
Why this form
Glucoraphanin and myrosinase generate sulforaphane in the body rather than relying on an unstable preformed version. A delayed-release capsule carries them past stomach acid, and sodium ascorbate supplies the cofactor myrosinase needs.
Glucoraphanin from broccoli seeds (Brassica oleracea). Myrosinase from mustard seed (Sinapis alba).
Hallmark context
Protect
Dihydroberberine
100 mg
What it does
Berberine activates AMPK, the same metabolic sensor activated by exercise and caloric restriction. It supports healthy glucose metabolism, lipid balance, and cellular energy regulation.
Berberine also has well-documented effects on gut microbiome composition. Some researchers believe the microbiome interaction is a primary driver of its metabolic benefits.
Why this form
Dihydroberberine is berberine's active metabolite, with roughly 5x the absorption of standard berberine. In a published human crossover study, 200 mg of dihydroberberine produced dramatically higher serum berberine than 500 mg of standard berberine — which is why we use less of it.
Berberine is found in goldenseal (Hydrastis canadensis), barberry (Berberis vulgaris), and Chinese goldthread (Coptis chinensis). Dihydroberberine is its reduced metabolite.
Hallmark context
Protect
Spermidine
10 mg
What it does
Spermidine is a naturally occurring polyamine studied in relation to autophagy, cellular recycling, and healthy aging biology. Dietary intake has also been examined in observational studies of healthy aging and mortality.
Why this form
Spermidine trihydrochloride provides a defined, stable form of this naturally occurring polyamine.
Found in wheat germ, soybeans, aged cheese, mushrooms, and fermented foods. Produced through fermentation.
Hallmark context
Protect
Vitamin K2 (MK-7, all-trans)
150 mcg
What it does
K2 supports osteocalcin (which directs calcium into bones) and matrix GLA protein (which helps keep calcium out of arterial tissue).
Completes the calcium utilization chain spanning Core and Protect: magnesium activates D3, D3 increases calcium absorption from Ca-AKG, and K2 ensures calcium goes where it should.
Why this form
MK-7 has a ~72 hour half-life vs a few hours for MK-4. All-trans isomer ensures maximum biological activity. Mixed-isomer products contain inactive cis-isomers.
Produced through bacterial fermentation from Bacillus subtilis natto.
Hallmark context
Protect
Piperine
5 mg
What it does
The most documented interaction is with curcumin.
Why this form
Standardized to a minimum of 95% piperine for consistent activity. Extracted from the fruit of Piper nigrum (black pepper).
Extracted from the fruit of Piper nigrum (black pepper).
Hallmark context
CLEANSE.
Clear Damaged Cells.
Feel: Lightness • Smooth digestion • Cellular renewal
RESET YOUR CELLULAR LANDSCAPE.
As we age, senescent cells can accumulate. Sometimes called “zombie cells,” they stop dividing but remain metabolically active, releasing inflammatory signals that can affect the tissue around them. CLEANSE is a two-day pulse built around compounds studied in cellular senescence biology, giving this hallmark of aging dedicated attention within Protocol 01.
Formula (Per Serving)
- Fisetin (Liposomal) (300 mg)
- Isoquercetin (150 mg)
- Bromelain 2400 GDU/g (micro encapsulated) (480 mg)
- Fenugreek Galactomannan (150 mg)
- Piperine (from Piper nigrum fruit) (5 mg)
- Vegan HPMC capsule with natural coloring
MONTHLY RENEWAL
Formulation highlights
01
Pulsed, not daily
Monthly Renewal is taken on two consecutive days each month, separate from the daily protocol.
02
Cellular-senescence research
Fisetin is a flavonoid widely studied in cellular-senescence research.
03
Liposomal fisetin
Fisetin is delivered in a liposomal format selected with formulation and bioavailability considerations in mind.
Monthly Renewal
Monthly Cleanse Ingredients
The monthly pulse. A short-duration formulation built around compounds studied in cellular senescence and healthy aging biology.
2 capsules, 2 consecutive days per month
Fisetin (Liposomal)
300 mg
A flavonoid extensively studied in cellular senescence and healthy aging research.
Learn more
Isoquercetin
150 mg
A bioavailable quercetin-class flavonoid included alongside fisetin.
Learn more
Bromelain
480 mg (2,400 GDU/g)
A proteolytic pineapple enzyme included for complementary inflammatory-response and formulation support.
Learn more
Fenugreek Galactomannan
150 mg
Prebiotic fiber supporting sustained absorption and gut health.
Learn more
Piperine
5 mg
Black pepper extract, included to support absorption of other compounds.
Learn more
That is the complete formula. Every compound, every dose, and the reason each one is in there.
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Monthly Renewal
Fisetin (Liposomal)
300 mg
What it does
Fisetin is a naturally occurring flavonoid found in foods including strawberries and apples. It has been studied for senolytic activity in preclinical models and for its relationship to cellular senescence and age-related biology.
Why this form
Liposomal delivery was selected because fisetin has low native aqueous solubility and limited oral bioavailability.
Found in strawberries, apples, persimmons, onions, and cucumbers. Strawberries have the highest dietary concentration.
Hallmark context
Monthly Renewal
Isoquercetin
150 mg
What it does
Isoquercetin is a glycoside form of quercetin studied for antioxidant, inflammatory-response, and cellular-health pathways. It complements fisetin with a structurally related flavonoid delivered in a more soluble form.
Why this form
The glucose group in isoquercetin improves solubility and absorption characteristics relative to standard quercetin.
Found in onions, apples, tarragon, and dill. Quercetin bonded to a glucose molecule for improved solubility.
Hallmark context
Monthly Renewal
Bromelain
480 mg (2,400 GDU/g)
What it does
Bromelain is a mixture of proteolytic enzymes derived from pineapple. It has been studied for its effects on protein breakdown and healthy inflammatory-response pathways.
Why this form
Standardized to 2,400 GDU/g to provide a defined level of proteolytic enzyme activity.
Extracted from the stem of the pineapple plant (Ananas comosus). The stem contains much higher bromelain concentrations than the fruit.
Hallmark context
Monthly Renewal
Fenugreek Galactomannan
150 mg
What it does
A soluble polysaccharide fiber that slows release of active senolytic compounds, supporting sustained absorption rather than a single rapid spike.
Forms a viscous gel in the digestive tract that modulates absorption timing. As a prebiotic fiber, it also feeds beneficial gut bacteria, supporting microbiome health.
Why this form
Extends the effective exposure window through a different mechanism than piperine, providing complementary absorption support.
Extracted from seeds of fenugreek (Trigonella foenum-graecum), a legume native to the Mediterranean and South Asia.
Hallmark context
Monthly Renewal
Piperine
5 mg
What it does
The most documented interaction is with curcumin.
Why this form
Standardized to a minimum of 95% piperine for consistent activity.
Extracted from black pepper fruit (Piper nigrum).
Hallmark context
FORMULATION INTELLIGENCE
How the System Works Together
Every ingredient was selected not just for individual efficacy, but for how it interacts with the rest of the protocol.
01 Synergy
Multi-pathway by design
Compounds are paired to reinforce each other within and across capsules, so NAD supply meets sirtuin demand and calcium gets routed rather than simply added.
02 Absorption
Engineered to actually absorb
Liposomal curcumin, fisetin and EGCG, dihydroberberine, and piperine. Delivery is built so the doses reach your cells instead of passing through.
03 Coverage
All twelve hallmarks
The four capsules map against the full matrix of aging biology, so no major pathway is left unsupported.
Compound synergies
Ingredients were selected for how they complement each other within and across capsules. Protocol 01 makes those pairings intentional rather than leaving you to build and manage them across a stack of separate bottles.
NMN + Pterostilbene (NAD supply meets sirtuin demand)
energizecore
Both sides of NAD biology
Apigenin + NMN (CD38 inhibition preserves NAD)
energize
Reduces NAD turnover
5-MTHF + methylcobalamin (methyl replenishment for NMN)
energize
Within-capsule synergy
D3 + K2 + magnesium + Ca-AKG (the calcium chain)
coreprotect
Four-compound pathway
Curcumin + piperine (absorption support)
protect
Protocol enhancer
Rhodiola + apigenin (complementary stress resilience)
energize
Acute and chronic
Glucoraphanin + myrosinase + sodium ascorbate
protect
Sulforaphane generated on demand
Fisetin + isoquercetin + bromelain (paired around cellular senescence biology)
monthly renewal
Within-capsule synergy
Most approaches to longevity focus on single pathways. But aging does not work that way. It emerges from interactions across biological systems, where the hallmarks influence and reinforce each other.
Dr. David Furman
Immunology and Systems Biology, Buck Institute and Stanford 1000 Immunomes Project
Science Advisory Board members are compensated for their advisory role.
REPLACE YOUR STACK
The real cost of doing this yourself.
BUILDING IT YOURSELF
$20+
per day at July 2026 retail pricing, before your time
15-20+ separate bottles from different vendors
Standard curcumin with near-zero absorption
No liposomal delivery, no delayed-release technology
NMN without CD38 inhibitors like apigenin
No integrated senolytic pulse protocol
Managing 15+ separate shipping cycles
PROTOCOL 01
$8.30
per day, everything included
One daily sachet + monthly senolytic pulse. 30 seconds.
Liposomal curcumin, fisetin, and EGCG for real absorption
Glucoraphanin + myrosinase + delayed-release protection
Apigenin inhibits CD38 to protect your NMN investment
Every compound paired with its synergy partner
One shipment. One box. Delivered quarterly.
Less than half the daily cost, and more than $4,000 saved a year. And instead of sourcing 15 to 20 bottles and dosing them yourself, Protocol 01 arrives pre-sorted into one 30-second daily ritual.
Why 6 capsules replace 20+.
Higher absorption.
Liposomal + delayed-release delivery
Smarter compounds.
Paired to work together, not stacked at random
Lower volume.
Bioavailability-optimized forms need less material
6
PROTOCOL 01
One daily sachet
REPLACES
20+
STANDARD SUPPLEMENTS
From 15+ separate bottles
The best protocol is the one you keep taking.
Supplement routines fail for one reason: people stop. Protocol 01 is one sachet a day, already sorted, so consistency is the easy part.
You are not paying for more capsules. You are paying for a precision-engineered system.
THE FORMULA
25 Ingredients. Zero Compromises.
Every ingredient earned its place through a framework considering mechanistic evidence, human data where available, formulation quality, and system fit.
core
Ca-AKG
1000 mg
Supports cellular energy metabolism and epigenetic regulation.
Learn more
core
Pterostilbene
50 mg
Supports sirtuin signaling, a pathway tied to cellular defense and DNA repair.
Learn more
core
Cycloastragenol
10 mg
Supports telomere biology, one of the twelve hallmarks of aging.
Learn more
core
Magnesium Bisglycinate
200 mg
Essential cofactor for 300+ enzymatic reactions and sleep quality.
Learn more
core
Vitamin B6 (P-5-P)
10 mg
Active coenzyme form supporting methylation and amino acid metabolism.
Learn more
energize
Beta-NMN
350 mg
Direct NAD+ precursor for cellular energy production.
Learn more
energize
Apigenin
50 mg
Flavonoid that inhibits CD38 to preserve NAD+ levels.
Learn more
energize
Urolithin A
500 mg
A postbiotic metabolite studied for muscle health and cellular energy biology.
Learn more
energize
Rhodiola Rosea
200 mg
Adaptogenic support for stress resilience, energy, and focus.
Learn more
energize
Liposomal EGCG
80 mg
Bioavailability-enhanced green tea extract for metabolic and antioxidant support.
Learn more
energize
Vitamin B9 Folate (5-MTHF)
500 mcg
Active methylfolate that bypasses the MTHFR conversion step.
Learn more
energize
Vitamin B12 (Methylcobalamin)
200 mcg
Active coenzyme B12 for methylation and neurological function.
Learn more
energize
Vitamin D3
50 mcg (2000 IU)
Supports immune regulation, bone health, and calcium metabolism.
Learn more
protect
Piperine
5 mg
Black pepper extract, included to support absorption of other compounds.
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protect
Sulforaphane Activation Complex
Glucoraphanin 70 mg + Myrosinase 50mg + Sodium Ascorbate (65 mg)
4-part system (3 compounds + delayed release capsule) generating fresh sulforaphane on demand (yields ~10-15 mg sulforaphane).
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protect
Dihydroberberine
100 mg
Enhanced berberine for metabolic support with 5x better bioavailability.
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protect
Spermidine
10 mg
A naturally occurring polyamine studied for its role in autophagy and cellular recycling.
Learn more
protect
Vitamin K2 (MK-7)
150 mcg
Supports normal calcium metabolism and bone health.
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protect
Liposomal Curcumin
150 mg
Liposomal curcumin, selected to support a healthy inflammatory response.
Learn more
cleanse
Fisetin (Liposomal)
300 mg
A flavonoid extensively studied in cellular senescence and healthy aging research.
Learn more
cleanse
Isoquercetin
150 mg
A bioavailable quercetin-class flavonoid included alongside fisetin.
Learn more
cleanse
Bromelain
480 mg (2,400 GDU/g)
A proteolytic pineapple enzyme included for complementary inflammatory-response and formulation support.
Learn more
cleanse
Fenugreek Galactomannan
150 mg
Prebiotic fiber supporting sustained absorption and gut health.
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cleanse
Piperine
5 mg
Black pepper extract included to support bioavailability.
Learn more
core
Ca-AKG
1000 mg
What it does
Alpha-ketoglutarate is central to the Krebs cycle and serves as a cofactor for DNA demethylation enzymes, connecting metabolism directly to epigenetic regulation.
Circulating AKG levels decline with age. Ca-AKG restores AKG in a stable, longevity-oriented calcium salt form.
Why this form
Delivers AKG directly in a calcium salt form rather than the arginine blend (AAKG) used in sports nutrition.
Produced naturally by every cell as part of the citric acid cycle. Supplemental Ca-AKG produced through chemical synthesis.
Impacted hallmarks
core
Pterostilbene
50 mg
What it does
A polyphenol from blueberries with roughly 4x the oral bioavailability of resveratrol. Supports sirtuin signaling, a pathway tied to DNA repair, mitochondrial function, and cellular stress resistance.
Why this form
Selected for its greater metabolic stability and improved absorption compared to standard resveratrol.
Found in blueberries (Vaccinium spp.), grapes, and the heartwood of the Indian kino tree.
Impacted hallmarks
core
Cycloastragenol
10 mg
What it does
Cycloastragenol is a triterpenoid saponin derived from Astragalus membranaceus, a plant with a long history in traditional Chinese medicine. It is one of a small number of compounds studied for its role in telomere biology. Telomeres are protective caps at the ends of chromosomes that shorten with each cell division. When they become critically short, cells enter senescence or die.
Why this form
A rare compound adding differentiated telomere-biology support uncommon in daily longevity formulas.
Extracted from the root of Astragalus membranaceus, native to northern China and Mongolia.
Impacted hallmarks
core
Magnesium Bisglycinate
200 mg
What it does
Involved in over 300 enzymatic reactions. An estimated 50% of adults do not meet adequate intake. Also activates vitamin D3 (Energize), creating cross-protocol synergy.
Why this form
Chelated form for superior absorption. Magnesium oxide has roughly 4% bioavailability. Bisglycinate absorbs significantly better with fewer GI issues.
Magnesium bonded to two molecules of glycine. Chelation protects the mineral through digestion.
Impacted hallmarks
core
Vitamin B6 (P-5-P)
10 mg
What it does
Involved in 100+ enzyme reactions. Essential for nervous and immune system function. Relevant for MTHFR gene variation carriers.
Why this form
Found naturally in potatoes, bananas, chickpeas, poultry, and fish. Potatoes are one of the richest whole-food sources of B6. Supplemental P-5-P is the pre-activated coenzyme form, manufactured to provide the active metabolite directly without requiring liver conversion.
P-5-P is the active metabolite of vitamin B6. Supplemental P-5-P is manufactured to provide the coenzyme directly. B6 is one of the most common micronutrient gaps in the modern diet, despite being abundant in everyday foods like potatoes and bananas.
Impacted hallmarks
energize
Beta-NMN
350 mg
What it does
Direct precursor to NAD+, required for hundreds of metabolic reactions. NAD+ declines significantly with age. NMN is one enzymatic step from NAD+.
The conversion consumes methyl groups, paired with 5-MTHF and methylcobalamin in the same capsule to replenish them.
Why this form
Selected over NR, niacin, and NAD+ for direct conversion pathway and growing human clinical data. Beta-NMN is the bioactive isomer.
Occurs naturally in broccoli, cabbage, avocado, and edamame. Produced through enzymatic biosynthesis.
Impacted hallmarks
energize
Apigenin
50 mg
What it does
Inhibits CD38, the enzyme degrading NAD+. NMN (Energize) adds NAD+. Apigenin reduces the rate it breaks down. Together they support both sides of NAD biology. Also supports healthy sleep.
Why this form
Included specifically for CD38 inhibition synergy with NMN. Also supports stress resilience alongside Rhodiola.
Found in chamomile, parsley, and celery.
Impacted hallmarks
energize
Urolithin A
500 mg
What it does
Urolithin A is a postbiotic metabolite that some gut microbiomes produce from ellagitannins found in foods such as pomegranates, walnuts, and certain berries. Direct supplementation provides a defined amount without relying on individual conversion from dietary precursors.
Why this form
Provided as urolithin A directly rather than as an ellagitannin precursor, giving a defined amount per serving independent of individual gut conversion.
Urolithin A is a gut-derived metabolite of ellagitannins found in pomegranates and other plant foods.
Impacted hallmarks
energize
Rhodiola Rosea
200 mg
What it does
Adaptogenic herb modulating the HPA axis for efficient stress response. Primary feel-factor ingredient. Synergizes with apigenin for complementary stress resilience.
Why this form
Root extract standardized for rosavins and salidroside.
Root of Rhodiola rosea, growing at high altitudes in arctic regions of Europe and Asia.
Impacted hallmarks
energize
Liposomal EGCG
80 mg
What it does
Most studied green tea polyphenol. Activates AMPK and Nrf2 pathway. Synergizes with Rhodiola in the same capsule.
Why this form
Standard EGCG degrades rapidly in the gut. Liposomal encapsulation protects through digestion and improves absorption.
Primary catechin in green tea (Camellia sinensis). Liposomal phospholipid delivery.
Impacted hallmarks
energize
Vitamin B9 Folate (5-MTHF)
500 mcg
What it does
Essential for methylation, DNA synthesis. 40-60% of people carry MTHFR variations impairing folic acid conversion. Paired with B12 to support the methylation cycle NMN depends on.
Why this form
5-methyltetrahydrofolate calcium bypasses the MTHFR bottleneck. Directly usable regardless of genetics.
Crystalline calcium salt of the naturally occurring L-form of 5-methyltetrahydrofolic acid.
Impacted hallmarks
energize
Vitamin B12 (Methylcobalamin)
200 mcg
What it does
Required for myelin synthesis, red blood cells, and methionine metabolism. Works with folate in the methylation cycle. Critical for MTHFR carriers.
Why this form
Provided as methylcobalamin, an active coenzyme form of vitamin B12 that can participate directly in B12-dependent metabolic pathways.
Naturally occurring B12 form. Supplemental form produced through fermentation.
Impacted hallmarks
energize
Vitamin D3
50 mcg (2000 IU)
What it does
Your body produces vitamin D3 naturally when ultraviolet light hits your skin. It is the only nutrient humans are designed to synthesize from sunlight. But modern indoor lifestyles mean most people no longer produce enough.
D3 functions more like a hormone than a vitamin, regulating over 1,000 genes. Deficiency affects an estimated 40% of U.S. adults.
Works in a four-ingredient synergy chain: magnesium (Core) activates D3, which increases calcium absorption from Ca-AKG (Core). K2 (Protect) then directs calcium to bones rather than soft tissue.
Why this form
Cholecalciferol from vegan lichen. Raises serum levels more effectively than D2. Plant-based source.
Derived from lichen. Suitable for vegan diets.
Impacted hallmarks
protect
Piperine
5 mg
What it does
Inhibits glucuronidation, extending compound circulation time. Enhances absorption across the entire protocol, not just this capsule.
Why this form
Patented extract, minimum 95% piperine. Consistent bioenhancer activity.
Fruit of Piper nigrum (black pepper).
Impacted hallmarks
protect
Sulforaphane Activation Complex
Glucoraphanin 70 mg + Myrosinase 50mg + Sodium Ascorbate (65 mg)
What it does
Sulforaphane is one of the most potent Nrf2 activators. Instead of unstable preformed sulforaphane, we deliver the precursor plus the enzyme. They meet in your digestive tract and generate fresh sulforaphane on demand.
Delayed-release capsule protects the system from stomach acid for optimal intestinal conversion.
Why this form
Glucoraphanin and myrosinase generate sulforaphane in the body rather than relying on an unstable preformed version. A delayed-release capsule carries them past stomach acid, and sodium ascorbate supplies the cofactor myrosinase needs.
Glucoraphanin from broccoli seeds (Brassica oleracea). Myrosinase from mustard seed (Sinapis alba).
Impacted hallmarks
protect
Dihydroberberine
100 mg
What it does
Activates AMPK for metabolic regulation. Well-documented gut microbiome effects may be a primary driver of metabolic benefits.
Why this form
Active metabolite with roughly 5x the absorption of standard berberine, so a lower dose delivers more.
Found in goldenseal, barberry, and Chinese goldthread. Dihydroberberine is the reduced metabolite.
Impacted hallmarks
protect
Spermidine
10 mg
What it does
Spermidine is a naturally occurring polyamine studied in relation to autophagy, cellular recycling, and healthy aging biology. Dietary intake has also been examined in observational studies of healthy aging and mortality.
Why this form
Spermidine trihydrochloride provides a defined, stable form of this naturally occurring polyamine.
Found in wheat germ, soybeans, aged cheese, mushrooms. Produced through fermentation.
Impacted hallmarks
protect
Vitamin K2 (MK-7)
150 mcg
What it does
Vitamin K2 supports the activation of vitamin K-dependent proteins including osteocalcin and matrix Gla protein, which are involved in normal calcium metabolism.
Why this form
MK-7 has ~72 hour half-life vs hours for MK-4.
Bacterial fermentation from Bacillus subtilis natto.
Impacted hallmarks
protect
Liposomal Curcumin
150 mg
What it does
Curcumin is the primary bioactive in turmeric and one of the most studied plant compounds in inflammation research. It modulates NF-kB, a master regulator of inflammatory gene expression.
Why this form
Standard curcumin has low oral bioavailability. Liposomal delivery was selected to improve its formulation and absorption characteristics.
Extracted from the rhizome of Curcuma longa (turmeric), native to South and Southeast Asia.
Impacted hallmarks
cleanse
Fisetin (Liposomal)
300 mg
What it does
Fisetin is a naturally occurring flavonoid found in foods including strawberries and apples. It has been studied for senolytic activity in preclinical models and for its relationship to cellular senescence and age-related biology.
Why this form
Liposomal delivery was selected because fisetin has low native aqueous solubility and limited oral bioavailability.
Found in strawberries, apples, persimmons, onions, cucumbers.
Impacted hallmarks
cleanse
Isoquercetin
150 mg
What it does
Isoquercetin is a glycoside form of quercetin studied for antioxidant, inflammatory-response, and cellular-health pathways. It complements fisetin with a structurally related flavonoid delivered in a more soluble form.
Why this form
The glucose group in isoquercetin improves solubility and absorption characteristics relative to standard quercetin.
Found in onions, apples, tarragon, dill. Quercetin bonded to glucose for solubility.
Impacted hallmarks
cleanse
Bromelain
480 mg (2,400 GDU/g)
What it does
Bromelain is a mixture of proteolytic enzymes derived from pineapple. It has been studied for its effects on protein breakdown and healthy inflammatory-response pathways.
Why this form
Standardized to 2,400 GDU/g to provide a defined level of proteolytic enzyme activity.
Stem of the pineapple plant (Ananas comosus). Higher concentration than the fruit.
Impacted hallmarks
cleanse
Fenugreek Galactomannan
150 mg
What it does
Soluble fiber slowing release of senolytic compounds for sustained absorption. Also feeds beneficial gut bacteria as a prebiotic.
Why this form
Extends exposure window through a different mechanism than piperine. Complementary absorption support.
Seeds of fenugreek (Trigonella foenum-graecum), a legume native to the Mediterranean.
Impacted hallmarks
cleanse
Piperine
5 mg
What it does
Piperine is a black pepper alkaloid studied for its effects on compound metabolism and bioavailability. Its best-documented pairing in this formula is with curcumin.
Why this form
Standardized black pepper extract providing a consistent amount of piperine.
Black pepper fruit (Piper nigrum).
Impacted hallmarks
LAUNCHING LATE SUMMER 2026
FOUNDER'S EDITION
Engineer a younger tomorrow.
Protocol 01 opens to a founding group in late summer 2026. Request your place.
$249/month · billed quarterly · about $8.30/day
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FOUNDING ACCESS
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